Harnessing endophytes and Multi-Omics for sustainable Colchicine biosynthesis.
Semwal P, Majhi B, Shivhare R, Mishra SK, Misra S
Crispr
Researchers demonstrate how beneficial microorganisms living inside Gloriosa superba plants boost colchicine production—a drug used for gout, arthritis, and cancer. By studying this plant-microbe partnership using advanced molecular techniques and applying genetic engineering, scientists can develop sustainable, scalable manufacturing methods while protecting endangered wild populations.
Key Findings
1
Endophytic fungi and bacteria enhance colchicine accumulation through elicitor-mediated signaling, transcriptional reprogramming, and metabolic complementation
2
Integrated multi-omics analyses identified cytochrome P450-mediated oxidative ring expansion as a critical bottleneck limiting colchicine pathway flux
3
CRISPR-based genome editing combined with synthetic pathway reconstruction in heterologous microbial hosts enables eco-efficient, scalable colchicine production
description
Abstract Preview
Gloriosa superba, an endangered medicinal plant, serves as the principal natural source of colchicine, a vital alkaloid used for treating gout, arthritis, cancer, and various inflammatory disorders...
Gloriosa superba is a species of flowering plant in the family Colchicaceae. Common names include flame lily, climbing lily, creeping lily, glory lily, gloriosa lily, tiger claw, and fire lily.
