Autophagy and stress tolerance in plants: the central role of ATG18-a review.
Wei S, Chen Z, Xu C, Qian X, Tang Q
Summary
7.8/10Plants use a cellular recycling system called autophagy to survive stress and recover damaged components. This review highlights how a key protein called ATG18 controls this survival mechanism, offering insights into improving crop resilience to environmental stress.
Key Findings
Autophagy recycles damaged organelles and nutrients, functioning as a central survival mechanism under both biotic and abiotic stress
ATG18 acts as a phosphatidylinositol 3-phosphate (PI3P) effector and is indispensable for plant survival under stress conditions
Three distinct autophagic pathways and core ATG machinery components work together to execute cellular recycling and stress responses
Original Abstract
Autophagy is an ancient, conserved system that underpins plant survival by recycling damaged organelles and nutrients under biotic and abiotic stress. This review synthesizes recent advances in three autophagic pathways in plants and the core ATG machinery that executes them. Among them, ATG18, functioning as a phosphatidylinositol 3-phosphate (PI3P) effector, is indispensable for plant survival under stress, underscoring its critical significance. By integrating biotic/abiotic signals