Majoon Ushba alleviated IL-17A sensitized keratinocyte ferroptosis via JAK-2-STAT-3 signaling axis and reversed imiquimod induced psoriasiform inflammation.
Rithvik A, Bhattacharjee S, Illanad GH, Kumar P, Javed G
Medicinal Plants
PubMedMedicinal plants used for centuries in traditional remedies are now being validated by modern lab science — meaning the herbs growing in apothecary gardens or sold at farmers markets may hold real, measurable benefits that go far beyond folk wisdom.
Psoriasis is a painful skin disease where the immune system attacks the skin, causing red, scaly patches. Scientists tested a traditional herbal blend called Majoon Ushba — made from multiple medicinal plants — and found it could calm the immune overreaction and protect skin cells from a specific kind of damage. Computer modeling also showed that natural chemicals from the plants physically latch onto the immune proteins that drive psoriasis, hinting at why the remedy works.
Key Findings
Majoon Ushba reduced levels of three key inflammatory immune signals — IL-17A, IL-23, and IFN-γ — in a mouse model of psoriasis
The herbal formulation improved GPX4 expression and regulated lipid peroxidation, protecting skin cells from ferroptosis (iron-driven cell death)
In-silico docking analysis showed favorable binding affinities of the formulation's plant-derived compounds to IL-17RA and STAT-3 immune targets
chevron_right Technical Summary
A traditional herbal remedy called Majoon Ushba, used in Unani medicine for skin conditions, was found to reduce the skin inflammation seen in psoriasis by blocking a specific immune signaling pathway and protecting skin cells from a type of cell death driven by iron imbalance.
Abstract Preview
Psoriasis is a relapsing autoimmune disease exacerbated by aberrant interleukin (IL)-17 A activity. Majoon Ushba, a unani polyherbal formulation implicated in clinical cases of psoriasis lacks immu...
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