Revealing the anaerobic biodegradation pathway and mechanism of sulfamethoxazole by a novel Cupidesulfovibrio sp. strain SA-9.
Liu J, Yang X, Gao T, Zhang Y, Pan D
Summary
6.5/10Researchers isolated a new anaerobic bacterium that breaks down sulfamethoxazole, a widely-used antibiotic that contaminates soil and water. This discovery could enable better environmental remediation and reduce antibiotic pollution that threatens agricultural soils.
Key Findings
Cupidesulfovibrio sp. strain SA-9 is a novel anaerobic bacterium capable of degrading sulfamethoxazole using lactate or pyruvate as electron donors
The bacterium utilizes sulfate, nitrate, or carbonate as electron acceptors to drive SMX degradation in oxygen-free environments
This is the first characterized pure-cultured anaerobe known to degrade SMX, revealing a previously unknown biodegradation pathway for antibiotic residues in soil
Original Abstract
The widespread use of sulfamethoxazole (SMX) has raised significant concerns regarding environmental residue pollution and the emergence of bacterial antibiotic resistance. Anaerobes play crucial roles in the biogeochemical element cycle and the degradation of organic pollutants; however, the pure-cultured anaerobes involved in SMX anaerobic degradation and their underlying mechanisms remain largely unknown. In this study, a novel anaerobic bacterium, Cupidesulfovibrio sp. strain SA-9, was isolated and characterized for its ability to degrade SMX. Strain SA-9 preferentially utilized lactate or pyruvate as electron donors and sulfate, nitrate, or carbonate as electron acceptors to drive SMX degradation. The degradation half-life (T