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Plant cells form temporary droplets to survive extreme stress

Mahi S, Rathod B, Puri S

Plant Signaling

The wilting basil or bolting lettuce in your garden during a heat wave is running an internal emergency system, tiny liquid droplets in its cells that rapidly rewire gene activity to cope before any visible damage appears.

When plants face heat, drought, salty soil, or disease, their cells don't have time to build new structures to respond. Instead, proteins and genetic material clump together into tiny liquid droplets, like oil beads in water, that form and dissolve in minutes to control which genes turn on or off. Scientists are now mapping how these droplets act as rapid-response hubs, though exactly how they work in each type of plant stress is still being worked out.

Key Findings

1

Biomolecular condensates formed by liquid-liquid phase separation (LLPS) act as membraneless regulatory hubs that link stress perception to gene expression changes in plants

2

Both abiotic stress (drought, heat) and biotic stress (pathogens) trigger remodeling of condensate structure and composition in the nucleus and cytoplasm

3

Condensates influence transcription factor activity, chromatin organization, RNA stability, and selective translation, and are reversibly tuned by post-translational modifications

chevron_right Technical Summary

Plant cells survive extreme heat, drought, and disease attacks by forming temporary molecular droplets inside themselves that act like pop-up emergency response centers, quickly switching genes on or off without needing dedicated compartments.

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Original paper

Emerging Roles of Biomolecular Condensates and Phase Separation in Plant Stress Adaptation and Gene Regulation.

Although plants are exposed to many environmental stressors (heat, drought, salinity, and pathogen), they survive by rapidly reprogramming their gene expression. Recent findings show that many regu...

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