Uncovering the bidirectional molecular pathway: How shugan wendan decoction treats concurrent depression and atherosclerosis.
Huang P, Peng W, Lu J, Feng Y, Zhang G
Summary
PubMedA traditional Chinese herbal remedy was found to treat both depression and atherosclerosis by regulating shared molecular pathways, suggesting these two diseases may be biologically linked and could benefit from the same herbal treatment.
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Key Findings
Depression and atherosclerosis exacerbate each other through dysregulation of proteins CASP1 and MMP9 in animal models of high-fat diet and chronic stress
Shugan Wendan Decoction reduced cholesterol levels, arterial lesions, depression-like behaviors, and stress hormones simultaneously in treated animals
Two distinct pathways connect the diseases: the Lipid and Atherosclerosis Pathway (depression worsens atherosclerosis) and the Tryptophan Metabolism Pathway (atherosclerosis increases depression risk)
Abstract Preview
Shugan Wendan Decoction (SGWDD) is a herbal remedy effective against atherosclerosis and depression, yet its mechanism for treating both conditions is not fully understood. This study seeks to conf...
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