[Biomanufacturing driven by engineered organisms (2026)].

In 2025, synthetic biology and biomanufacturing have demonstrated remarkable progress characterized by intelligent integration, systematic optimization, and diversified applications. Artificial intelligence has evolved from an auxiliary tool into a core driving force, deeply embedded throughout the entire pipeline from biomolecular design to fermentation process control, catalyzing a fundamental shift from "experience-driven" to "data- and model-driven" research paradigms. Breakthroughs in enzyme engineering and protein design continue to expand the functional boundaries of biocatalysis, while cell factory construction is advancing from single-target modification toward global systematic optimization. The synergistic development of traditional and emerging chassis hosts enables efficient biosynthesis of high-value chemicals and novel proteins. Environmental bioremediation is transitioning from functional strain engineering to the rational design of synthetic microbial consortia, marking a new era of predictable and controllable remediation strategies. Meanwhile, advances in interdisciplinary frontiers, such as artificial cells, are continuously expanding the horizons of biomanufacturing. Looking forward, the deep integration of artificial intelligence with automation platforms, a deeper understanding of biological complexity, and industrial applications aligned with carbon neutrality goals and human health demands will define the future trajectory of the field. Synthetic biomanufacturing is evolving from "understanding life by creating life and creating life for applications" toward "creating life for good and creating life for the future", offering indispensable solutions to address global challenges in resources, environment, and health.