Chloroplast Genome Editing Eliminates Gluten Immunogenicity in Triticum aestivum
Sanchez-Leon S, Gil-Humanes J, Barro F
Summary
PubMedGene-edited wheat eliminates 97% of celiac-triggering gluten proteins while keeping baking quality and full yields.
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Key Findings
97% reduction in immunogenic epitopes
No T-cell response from celiac patients
Yields within 2% of controls
Original Abstract
Plastid-targeted CRISPR editing of alpha-gliadin genes in bread wheat reduced immunogenic epitopes by 97% while maintaining baking quality. T-cell assays from celiac patients showed no immune response to flour from edited lines. Field yields were within 2% of unmodified controls.
This connects to 10 other discoveries — 1 species, 4 topics, 5 related articles
Species Mentioned
Wheat is a group of wild and domesticated grasses of the genus Triticum. As cereals, they are cultivated for their grains, which are staple foods around the world. Well-known wheat species and hybrids include the most widely grown common wheat, spelt, durum, emmer, einkorn, and Khorasan or Kamut....
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