3,5-Dicaffeoylquinic Acid Delayed Aging and Promoted Oxidative Stress Tolerance via Activation of the SKN-1/Nrf2 Signaling Pathway.
Li R, Tao M, Yuan J, Huang Y, Xu T
Summary
7.2/10A plant-derived compound called 3,5-diCQA extends lifespan and helps cells resist aging by activating a protective cellular stress-response pathway. This suggests plant polyphenols may be candidates for age-related disease prevention.
Key Findings
3,5-diCQA demonstrates anti-inflammatory, antioxidant, and anti-diabetes bioactivities
The compound increases lifespan and healthspan in model organisms
Benefits are mediated through SKN-1/Nrf2 signaling pathway activation, a master regulator of cellular stress resistance
Original Abstract
3,5-Dicaffeoylquinic acid (3,5-diCQA), as a plant-derived polyphenol, exhibits multiple bioactivities, including anti-inflammation, antioxidation, and anti-diabetes. A previous report demonstrated that 3,5-diCQA increased the lifespan and promoted the healthspan in