Endophytic Fungi in Cannabis sativa Produce Novel Terpene Synthases
Martinez R, Hesse B, Yamamoto K
Summary
PubMedFungi living inside cannabis plants produce 3 brand-new anti-inflammatory compounds not found anywhere else in nature.
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Key Findings
7 novel fungal terpene synthases
3 new sesquiterpenes with anti-inflammatory activity
IC50 2-8 uM for inflammation
Original Abstract
Metagenomic analysis of cannabis endophytes identified 7 fungal terpene synthase genes with no close homologs in public databases. Heterologous expression yielded 3 novel sesquiterpenes with anti-inflammatory activity (IC50 2-8 uM), expanding the chemical space accessible through plant-fungal partnerships.
This connects to 8 other discoveries — 1 species, 4 topics, 3 related articles
Species Mentioned
Cannabis is a genus of flowering plants in the family Cannabaceae that is widely accepted as being indigenous to and originating from the continent of Asia. However, the number of species is disputed, with as many as three species being recognized: Cannabis sativa, C. indica, and C. ruderalis. Al...
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