microbiome-therapy
Microbiome therapy is the application of beneficial microorganisms to enhance plant health and productivity by optimizing the plant's microbial ecosystem. This approach is significant in plant science because plants depend on diverse microbial partnerships for critical functions including nutrient acquisition, disease resistance, and stress tolerance—making microbiome management a key strategy for improving crop performance and agricultural sustainability.
PubMed · 2026-01-01
Plant-derived small extracellular vesicles (SMEVs) administered orally can treat diabetic kidney disease by reshaping gut bacteria and restoring metabolic balance, showing potential as a novel plant-based therapy for this common diabetes complication.
SMEV particles (~163.6 nm diameter) reduced proteinuria and renal fibrosis in diabetic mice after 6 weeks of oral treatment
16S rRNA sequencing showed SMEVs increased beneficial bacterial taxa while suppressing pathogenic bacteria, fundamentally reshaping the gut microbiome
Metabolomics analysis revealed upregulation of bioactive peptides (e.g., Tyr-Leu-His) and unsaturated fatty acids (e.g., petroselinic acid) with reduced pro-inflammatory lipids